Study Finds Key Genetic Targets for Alzheimer’s Disease Using Mendelian Randomization
Researchers of a study focused on identifying novel therapeutic targets for Alzheimer’s disease (AD) using Mendelian randomization (MR), a method helpful in repurposing licensed drugs and discovering new therapeutic targets. The researchers integrated druggable genes with blood and brain expression quantitative trait loci (eQTLs) to estimate their causal effects on AD. They validated identified genes through repeat studies with different eQTL data sources and explored potential mechanisms by evaluating the causal relationship between established AD markers.
Research Links Early Alzheimer’s Symptoms to Neurodegeneration, Advances Targeted Treatments
Findings link behavioral and psychological symptoms of dementia (BPSD) with early stages of Alzheimer’s disease (AD) pathogenesis and greater amyloid deposition, suggesting that these symptoms are core expressions of the neurodegenerative process rather than secondary responses. Understanding the neuropathology of BPSD in AD is crucial for developing effective treatments. Transgenic animal models exhibiting amyloid and tau pathologies provide insights into early behavioral symptoms in AD, aiding in identifying new pharmacological targets for specific BPSD like aggression and agitation.
Alzheimer’s Disease Research Advances: 187 Trials Test 141 Innovative and Repurposed Treatments
The pursuit of effective treatments for Alzheimer’s disease (AD) and mild cognitive impairment (MCI) attributed to AD is marked by a robust pipeline of clinical trials. A comprehensive search of ClinicalTrials.gov revealed a total of 187 ongoing trials across various phases, evaluating 141 unique treatments. A significant portion of these trials, 79%, focus on disease-modifying therapies. Additionally, 28% of the therapies under investigation are repurposed agents, originally developed for other conditions.
Study Shows Mediterranean, DASH Diets May Lower Alzheimer’s Risk, Despite Economic Hurdles
Authors of a review delved into the genetic underpinnings of Alzheimer’s disease (AD), the impact of dietary patterns on its prevention, and the socioeconomic challenges associated with dietary-based prevention strategies. Employing the MeSH search method and network analysis via VOS viewer, the findings underscore the significant impact of diets like the Mediterranean diet and DASH on reducing the risk of developing AD.
