Researchers of a study delved into the advancements in Alzheimer’s disease (AD) research, focusing on understanding its neuropathology and developing potential treatments. They also reexamined the role of amyloid-beta as a component of the brain’s immune response and explored how chronic inflammation may influence the development of the disease. Tau neurofibrillary tangles, researchers noted, are increasingly seen as a primary cause of cognitive impairment in AD, with new imaging techniques enabling the study of tau’s distribution in living patients. Moreover, attention is being given to AD-mimicking diseases such as limbic-predominant age-related TDP-43 encephalopathy and primary age-related tauopathy, both of which can mimic AD symptoms but have distinct pathologies.

Finally, the review highlights the growing importance of non-pharmacological strategies in managing both early and late-stage AD symptoms, emphasizing the need for a multifaceted approach in addressing the cognitive and behavioral challenges of this complex disease.

Reference: Marin A, Budson AE. Recent advances in understanding Alzheimer’s Disease: diagnosis and management strategies. Fac Rev. 2023;12:24. doi: 10.12703/r/12-24.